What is ketamine?
Buy Special Ketamine K kit KitKat super k or horse trank online. Ketamine is used by medical practitioners and veterinarians as an anesthetic. It’s sometimes used illegally by people to get high.
Ketamine is a dissociative drug, which means it acts on different chemicals in the brain to produce visual and auditory distortion, and a detachment from reality.
When it’s sold illegally, ketamine usually comes as a white or off-white powder. It can also be made into pills, or dissolved in a liquid.
Clinical trials and studies are assessing ketamine as a treatment for depression. Early indications show good results.
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First things first: You may be asking yourself, “What is ketamine?” Well, it was once used mainly as an anesthetic on battlefields and in operating rooms. Now this medication is gaining ground as a promising treatment for some cases of major depression, which is the leading cause of disability worldwide. In the US, recent estimates show 16 million adults had an episode of major depression in the course of a year. Suicide rates rose substantially between 1999 and 2016, increasing by more than 30% in 25 states. Because of its rapid action, ketamine could have a role to play in helping to prevent suicide.
Why is ketamine exciting for treating depression?
If a person responds to ketamine, it can rapidly reduce suicidality (life-threatening thoughts and acts) and relieve other serious symptoms of depression. Ketamine also can be effective for treating depression combined with anxiety.
Other treatments for suicidal thoughts and depression often take weeks or even months to take effect, and some people need to try several medications or approaches to gain relief. This is true for talk therapies, antidepressant medicines, transcranial magnetic stimulation (TMS), and electroconvulsive therapy (ECT), which is currently the most effective treatment for major depression that fails to respond to other therapies.
Are there different types of ketamine?
Two main types of ketamine are used to treat major depression that hasn’t responded to two or more medications (treatment-resistant depression).
- Racemic ketamine, which is most often given as an infusion into the bloodstream. This is sometimes called intravenous, or IV, ketamine. It is a mixture of two mirror-image molecules: “R” and “S” ketamine. While it was approved decades ago as an anesthetic by the FDA, it is used off-label to treat depression.
- Ketamine (Spravato), which the FDA approved in March, is given as a nasal spray. It uses only the “S” molecule.
Thus far, most research has been on ketamine infusions.
The two forms of ketamine interact differently with receptors in the brain. The delivery of ketamine and the type given affect drug effectiveness and side effects. We don’t yet know which type is more effective or how much side effects may differ. Further research comparing effectiveness and side effects is needed.
How does ketamine work?
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It’s not entirely clear how ketamine works. Because it exerts an antidepressant effect through a new mechanism, ketamine may be able to help people successfully manage depression when other treatments have not worked.
One likely target for ketamine is NMDA receptors in the brain. By binding to these receptors, ketamine appears to increase the amount of a neurotransmitter called glutamate in the spaces between neurons. Glutamate then activates connections in another receptor, called the AMPA receptor. Together, the initial blockade of NMDA receptors and activation of AMPA receptors lead to the release of other molecules that help neurons communicate with each other along new pathways. Known as synaptogenesis, this process likely affects mood, thought patterns, and cognition.
Ketamine also may influence depression in other ways. For example, it might reduce signals involved in inflammation, which has been linked to mood disorders, or facilitate communication within specific areas in the brain. Most likely, ketamine works in several ways at the same time, many of which are being studied.
What are the possible side effects of ketamine?
All drugs have side effects. When someone is suicidal or severely depressed, possible benefits may outweigh possible risks.
Ketamine given by infusion may cause:
- high blood pressure
- nausea and vomiting
- perceptual disturbances (time appearing to speed up or slow down; colors, textures, and noises that seem especially stimulating; blurry vision)
- dissociation (sometimes called out-of-body experiences); rarely, a person may feel as if they are looking down on their body, for example.
Generally, any changes in perception or dissociation are most noticeable during the first infusion and end very quickly afterward.
Ketamine nasal spray may cause the same side effects. However, the timing and intensity of those effects is different.
Long-term or frequent use of ketamine may have additional side effects. More research on this is needed.
What else should you know about ketamine?
- A much lower dose of ketamine is given for depression compared with the dose necessary for anesthesia.
- Like opioids, ketamine has addictive properties. It’s important to understand this when weighing risks and benefits. If you have a history of substance abuse –– such as alcohol or drugs –– it’s especially important for you and your doctor to consider whether ketamine is a good option for you.
- When IV (racemic) ketamine works, people usually respond to it within one to three infusions. If a person has no response at all, further infusions are unlikely to help. Instead, it’s probably best to try other treatments for depression.
- People who experience some relief from depression within one to three ketamine treatments are probably likely to extend these positive effects if the treatment is repeated several more times. The subsequent sessions may help prolong the effects of ketamine, rather than achieving further dramatic relief of symptoms. There are no standard guidelines for this. Many studies offer eight treatments initially (acute phase). After this, patient and doctor decide whether to taper or stop ketamine treatments or continue treatments at longer intervals.
How is it used?
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Ketamine can be swallowed, snorted or injected. It’s also sometimes smoked with cannabis or tobacco. The effects of ketamine may be experienced within one minute if injected, 5–15 minutes if snorted, and up to 30 minutes if swallowed. Its effects can last for around an hour, however an individual’s coordination or senses may be affected for up to 24 hours after initial use.
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There is no safe level of drug use. Use of any drug always carries some risk. It’s important to be careful when taking any type of drug.
Ketamine affects everyone differently, based on:
- size, weight and health
- whether the person is used to taking it
- whether other drugs are taken around the same time
- the amount taken
- the strength of the drug (varies from batch to batch)
The following effects may be experienced:
- feeling happy and relaxed
- feeling detached from your body (‘falling into a k-hole’)
- visual and auditory hallucinations
- confusion and clumsiness
- increased heart rate and blood pressure
- slurred speech and blurred vision
- anxiety, panic and violence
- lowered sensitivity to pain3,4,6
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If you take a large amount of ketamine or have a strong batch, you could overdose.
The risk of death from ketamine alone is low, due to its ability to cause unconsciousness with minimal impact on airway reflexes or blood circulation.5 However, individuals are at a higher risk of physical harm/accidents while under the influence of the ketamine.5
- Call an ambulance straight away by dialling triple zero (000) if you or someone else has any of these symptoms (ambulance officers don’t need to involve the police): inability to move, rigid muscles
- high blood pressure, fast heartbeat
- unconsciousness and ‘near death’ experiences
- death. 3,6,5
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The day after using ketamine, you may experience:
- memory loss
- impaired judgement, disorientation
- aches and pains
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Regular use of ketamine may eventually cause:
- poor sense of smell (from snorting)
- mood and personality changes, depression
- poor memory, thinking and concentration
- abnormal liver or kidney function
- ketamine bladder syndrome (see below)
- abdominal pain
- needing to use more to get the same effect
- dependence on ketamine
- financial, work and social problems3,6
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Large, repeated doses of ketamine may eventually cause ‘ketamine bladder syndrome’, a painful condition needing ongoing treatment.
Symptoms include difficulty holding in urine, incontinence, which can cause ulceration in the bladder.
Anyone suffering from ketamine bladder syndrome needs to stop using ketamine and see a health professional.3
Using ketamine with other drugs
The effects of taking ketamine with other drugs– including over-the-counter or prescribed medications – can be unpredictable and dangerous, and could cause:
- Ketamine + alcohol or opiates: When used with other depressant drugs, the combined effects may lead to the functioning of the heart or lungs to slow or stop, and can result in death.68
- Ketamine + amphetamines, ecstasy and cocaine: enormous strain on the body, which can lead to fast heart rate.3,8
‘Polydrug use’ is a term for the use of more than one drug or type of drug at the same time, or one after another. Polydrug use can involve both illicit drugs and legal substances, such as alcohol and medications. Find out more about polydrug use.
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Giving up ketamine after a long time is challenging because the body has to get used to functioning without it. Please seek advice from a health professional. Symptoms include:
- cravings for ketamine
- no appetite
- chills, sweating
- restlessness, tremors
- nightmares, anxiety, depression
- irregular and rapid heartbeat
- risk of inujry3
Other names of ketamine
- Blind Squid
- Cat Valium
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